75-90-1 Hemiaminals of trifluoroacetaldehyde, as trifluoromethylating agents

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Hemiaminals of trifluoroacetaldehyde are new trifluoromethylating agents. These reagents are synthesised from amines and gaseous trifluoroacetaldehyde. tBuONa is able to deprotonate the hemiaminals to form trifluoromethyl anion equivalents CF₃CH(O^-)NMe₂. The trifluoromethyl anion has been transferred from such intermediates to benzaldehyde yielding phenyl (trifluoromethyl) methanol.