73-22-3 Modular control ofl-tryptophan isotopic substitutionviaan efficient biosynthetic cascade

https://www.lookchem.com/CASDataBase_73-22-3.htm

Isotopologs are powerful tools for investigating biological systems. We report a biosynthetic-cascade synthesis of Trp isotopologs starting from indole, glycine, and formaldehyde using the enzymesl-threonine aldolase and an engineered β-subunit of tryptophan synthase. This modular route to Trp isotopologs is simple and inexpensive, enabling facile access to these compounds.

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