175591-22-7 NEW SYNTHESIS OF TAPENTADOL-HCl INTERMEDIATES

The present invention relates to a process for the synthesis of tapentadol intermediates comprising the following route of synthesis: (I) → (II) → (III) → (IV) → (V). https://www.lookchem.com/CASDataBase_175591-22-7.htm

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726-18-1 Electrophilic alkylations in neutral aqueous or alcoholic solutions

Acid-free Friedel-Crafts chemistry: A paradox? Nucleophilicity scales, based on reactions with benzhydrylium ions, show that many π systems are more nucleophilic than aqueous or alcoholic solutions that are generally employed as solvents for S N 1 reactions. Solvolytically generated carbocations can, therefore, be trapped by donor-substituted arenes and alkenes to form products of Friedel-Crafts-type reactions in neutral aqueous solutions (see scheme). https://www.lookchem.com/CASDataBase_726-18-1.htm
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1023-17-2 Syntheses, structures, and catalytic activity in Friedel–Crafts acylations of substituted tetramethylcyclopentadienyl molybdenum carbonyl complexes

Reactions of the substituted tetramethylcyclopentadienes [C 5 HMe 4 R] [R?=? t Bu, Ph, CH 2 CH 2 C(CH 3 ) 3 ] with Mo(CO) 3 (CH 3 CN) 3 in refluxing xylene gave a series of dinuclear molybdenum carbonyl complexes [(η 5 -C 5 Me 4 R)Mo(CO) 3 ] 2 [R?=? t Bu (1), Ph (2), CH 2 CH 2 C(CH 3 ) 3 (3)], [(η 5 -C 5 Me t Bu)Mo(μ-CO) 2 ] 2 (4)], and [(η 5 -C 5 Me 4 ) t Bu] 2 Mo 2 O 4 (μ-O) (5)], respectively. Complexes 1–5 were characterized by elemental analysis, IR, 1 H NMR, and 13 C NMR spectroscopy. In addition, their crystal structures were determined by X-ray crystal diffraction analysis. The catalytic activities of complexes 1–3 in Friedel–Crafts acylation in the presence of o-chloranil has also been investigated; the reactions were achieved under mild conditions to give the corresponding products in moderate yields. https://www.lookchem.com/CASDataBase_1023-17-2.htm
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75-26-3 Thallium(I) Carboxylate Modification of the Hunsdiecker Reaction

Treatment of a thallium(I) carboxylate with 1 molar equivalent of bromine gives the corresponding thallium(III) carboxylate dibromide.High yields of primary alkyl bromides are obtained if the thallium(III) carboxylate dibromide is treated with 0.5 mol equiv. of bromine in refluxing carbon tetrachloride.Pyrolysis of the thallium(III) derivative in the absence of added bromine gives a low yield of the corresponding alkyl bromide.The use of thallium(I) carboxylates for the preparation of alkyl bromides in high yields is limited to the salts of primary carboxylic acids.A simple procedure for the preparation of alkyl bromides from carboxylic acids using thallium(I) carbonate has been developed. https://www.lookchem.com/CASDataBase_75-26-3.htm
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