1008-76-0 Dopamine/serotonin receptor ligands. 10: SAR studies on azecine-type dopamine receptor ligands by functional

On the basis of the benz[d]indolo[2,3-g]azecine derivative 1 (LE300), structure-activity relations were investigated in order to identify the pharmacophore in this new class of ligands. Various structural modifications were performed and the inhibitory activities at human cloned D1, D2L, and D5 receptors were measured by using a simple fluorescence microplate reader based calcium assay. Subsequently, the affinities of active compounds were estimated by radioligand binding experiments, Deleting one of the aromatic rings as well as replacing it by a phenyl moiety abolishes the inhibitory activities almost completely. Contraction of the 10-membered central ring decreases them significantly. The replacement of indole by thiophene or N-methylpyrrole reduces the inhibitory activity, whereas replacing the indole by benzene increases it. Finally, the hydroxylated dibenz[d,g]azecine derivative 11d (LE404) was found to be more active than the lead 1 in the functional calcium assay as well as in radioligand displacement experiments. https://www.lookchem.com/CASDataBase_1008-76-0.htm

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1023-17-2 Syntheses, structures, and catalytic activity in Friedel–Crafts acylations of substituted tetramethylcyclopentadienyl molybdenum carbonyl complexes

Reactions of the substituted tetramethylcyclopentadienes [C 5 HMe 4 R] [R?=? t Bu, Ph, CH 2 CH 2 C(CH 3 ) 3 ] with Mo(CO) 3 (CH 3 CN) 3 in refluxing xylene gave a series of dinuclear molybdenum carbonyl complexes [(η 5 -C 5 Me 4 R)Mo(CO) 3 ] 2 [R?=? t Bu (1), Ph (2), CH 2 CH 2 C(CH 3 ) 3 (3)], [(η 5 -C 5 Me t Bu)Mo(μ-CO) 2 ] 2 (4)], and [(η 5 -C 5 Me 4 ) t Bu] 2 Mo 2 O 4 (μ-O) (5)], respectively. Complexes 1–5 were characterized by elemental analysis, IR, 1 H NMR, and 13 C NMR spectroscopy. In addition, their crystal structures were determined by X-ray crystal diffraction analysis. The catalytic activities of complexes 1–3 in Friedel–Crafts acylation in the presence of o-chloranil has also been investigated; the reactions were achieved under mild conditions to give the corresponding products in moderate yields. https://www.lookchem.com/CASDataBase_1023-17-2.htm
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7440-47-3 Influence of pulse plating on the crystal structure and orientation of chromium

Chromium deposits with various structures and orientations were prepared by pulse plating from a sulfate-catalyzed chromic acid solution and without formic acid addition. The influences of the puls duration, off-time, curent density, formic acid concentration, and plating time on the structure and orientation were studied by X-Ray diffraction and transmition electron microcsopy. https://www.lookchem.com/CASDataBase_7440-47-3.htm
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1792-81-0 Phenol and dihydroxybenzene hydrogenation catalysts based on polyamide dendrimers and rhodium species

Heterogeneous catalysts based on rhodium nanoparticles and first- and second-generation poly(amidoamine) (PAMAM) dendrimers crosslinked with hexamethylene diisocyanate have been synthesized. It has been found that catalyst samples with a particle size of 0.88 to 1.96 nm, depending on the PAMAM dendrimer generation, are effective in the hydrogenation of phenol, hydroquinone, resorcinol, and pyrocatechol (85°C, 30 atm O 2 , 2 h). In phenol hydrogenation, the selectivity for cyclohexanone is 100%. Cyclohexanone has not undergone further transformation under the reaction conditions. The main products of dihydroxybenzene hydrogenation have been trans-cyclohexanediols, with their proportion decreasing in the order: resorcinol > hydroquinone > pyrocatechol. The selectivity has been found to be 100% for 1,3-cyclohexanediol, 97-99% for 1,4-cyclohexanediol, and 33-91% for 1,2-cyclohexanediol. The catalysts based on the second-generation dendrimer have shown a high activity in dihydroxybenz...
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