172923-77-2 New strategy for the total synthesis of macrosphelides A and B based on ring-closing metathesis

(Matrix presented) A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a macrocyclization step is described. The substrate of the RCM could be synthesized from readily available chiral materials, methyl (S)-(+)-3-hydroxybutyrate and methyl (S)-(-)-lactate, with a high efficiency. The RCM proceeded in the presence of Grubbs' Ru-complex, providing a new effective synthetic route to these natural products. https://www.lookchem.com/CASDataBase_172923-77-2.htm

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